The Relationship between Anti-mullerian Hormone and Prolactin Levels in Polycystic Ovarian Syndrome

INTRODUCTION: This study aimed to investigate serum anti-Mullerian hormone (AMH) and prolactin levels in polycystic ovarian syndrome (PCOS) according to the presence of oligomenorrhea.
METHODS: Women with PCOS who were admitted to an endocrinology outpatient clinic consecutively between January and December 2020 were enrolled in this study retrospectively. The age of the patients included in this study was between 18 and 40 years. Patients diagnosed with PCOS according to Rotterdam revised criteria. Demographic and clinical characteristics of the patients were obtained from patients’ files.
RESULTS: A total of 301 women with PCOS were enrolled in this study. The mean prolactin levels were 20.0±8.5 ng/mL and 22.2±5.5 ng/mL in PCOS patients with and without oligomenorrhea (p=0.091). No significant differences in AMH levels were also found between the two groups 5.3 (5.2–5.4) versus 5.3 3 (5.0–6.0) ng/mL, respectively (p=0.798). AMH levels were positively correlated with prolactin and negatively with follicular-stimulating hormone in PCOS subjects (r=0.512, p<0.001, r=−0.155, p=0.007, respectively). The oligomenorrhea group demonstrated increased serum glucose and Vitamin D levels and platelet distribution width value and decreased glycated hemoglobin, estradiol, free testosterone, hemoglobin, and red cell distribution width values (p<0.001, p=0.017, p=0.018, p=0.001, p=0.008, p=0.027, p=0.001, and p=0.010, respectively). In addition, serum prolactin had a relationship between free testosterone and vitamin D levels (r=0.210, p<0.001; r=−0.123, p=0.320, respectively).
DISCUSSION AND CONCLUSION: AMH and prolactin levels did not differ in PCOS patients with and without oligomenorrhea.