INTRODUCTION: Hydroxymethylglutaryl-coenzyme A inhibitors (statins) which are used in the treatment of hyperlipidemia (HL) and which are the most efficacious and most widely used drug especially in decreasing low density lipoprotein cholesterol (LDL-C) have been found to decrease mortality and morbidity in coronary artery disease in a great number of studies and be beneficial in preventing stroke in recent studies. However, development of depression in patients under statin treatment has been evaluated in a very few number of studies. The aim of this study is to evaluate the influence of treatment by statin and statin derivatives on anxiety and depression.
METHODS: This study is a prospective observational study performed in 219 patients who were started on statin treatment for HL. The patients were found to be administered atorvastatin or rozuvastatin, 10 mg each for the treatment of HL. Those patients were followed-up for a period of 10 months. Pre- and post-treatment status of anxiety and depression of the patients was evaluated using hospital anxiety and depression scale and pre-and post-treatment scales were compared.
This study was performed in a total of 219 patients who were diagnosed to have HL
and whose age range was 33 and 87 years and were composed of 147 (67,0%) females and 72 males (32,9%). As treatment, 194 (88,5%) and 25 (11,5%) patients were found to be administered atorvastatin 10 mg and rosuvastatin 10 mg, respectively. It was observed that 6,8% (n=16) of the patients had borderline anxiety both before and after the treatment; 13,7% (n=30) of patients had borderline depression before the treatment, and 13.2% (n=29) of patients had borderline depression after the treatment.
No statistically significant differences were found between the rates of anxiety and depression prior to and after the treatment in the study group
DISCUSSION AND CONCLUSION: Statins are among the most frequently used drug groups for longterm treatment of HL.No significant association was found in this study between statin and depression or anxiety.