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The Anatolian Journal of Family Medicine Cortisol metabolism in obese women with normal and impaired glucose tolerance [anatol j fm]
anatol j fm. Ahead of Print: ANATOLJFM-46036 | DOI: 10.5505/anatoljfm.2021.46036

Cortisol metabolism in obese women with normal and impaired glucose tolerance

Kağan Güngör1, Nur Dokuzeylul Gungor2, MUSTAFA SAIT GONEN3
1İstanbul Medeniyet University Göztepe Training And Research Hospital Department Of Endocrinology And Metabolism
2Bahçeşehir University Göztepe Medical Park Hospital Reproductive Endocrinology And Ivf Unit
3Istanbul University Cerrahpasa Faculty Of Medicine, Department Of Endocrinology And Metabolism

INTRODUCTION: Increases in fasting plasma cortisol level in the morning has been associated with glucose intolerance and insulin resistance in patients with metabolic syndrome. In this study, we investigated the relationship between fasting morning cortisol and insulin resistance defined by homeostasis model assessment for insulin resistance (HOMA-IR) in obese women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT).
METHODS: Total body fat mass, lean body mass, total body fluid, and basal metabolic rate were calculated via TANITA. Patients’ BMI, fasting plasma glucose, insulin, HOMA-IR, basal cortisol, 24-hour urinary free cortisol, overnight dexamethasone suppression test, lipids, OGTT results and thyroid function tests were obtained from their patient files in the obesity clinic.
RESULTS: Total body fat mass, lean body mass, total body fluid, and basal metabolic rate were calculated via TANITA. Patients’ BMI, fasting plasma glucose, insulin, HOMA-IR, basal cortisol, 24-hour urinary free cortisol, overnight dexamethasone suppression test, lipids, OGTT results and thyroid function tests were obtained from their patient files in the obesity clinic.
DISCUSSION AND CONCLUSION: Although basal cortisol levels of NGT and IGT patients were similar, in patients with IGT, there was a strong correlation between basal cortisol and HOMA-IR.

Keywords: obesity, pseudo-Cushing syndrome, insulin resistance, impaired glucose tolerance



Corresponding Author: Kağan Güngör, Türkiye
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