INTRODUCTION: This study aimed to evaluate the relationship between non-HDL cholesterol level, which is a risk factor for coronary artery disease (CAD), and Syntax score.
METHODS: This retrospective study included patients less than 45 years of age who underwent coronary angiography with a diagnosis of acute coronary syndrome between August 2015 and July 2020. Syntax scores of the patients were evaluated by two experienced cardiologists using the www.syntaxscore.com version on 2.28. Metabolic parameters such as total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride and HbA1c of the patients were obtained from their files. Non-HDL cholesterol levels were calculated by subtracting HDL cholesterol from total cholesterol.
RESULTS: In total, 296 patients were included in this study, 264 (89.1%) of patients were male. The mean Syntax score of the patients was 16.7±6.5. A significant positive correlation was determined between the Syntax score and non-HDL cholesterol, total cholesterol, LDL cholesterol, triglyceride, whereas a negative correlation was noted between the Syntax score and HDL cholesterol value (r=0.360 and p<0.001; r=0.426 and p<0.001; r=0.414 and p<0.001; r=0.388 and p=0.001; r=-0.396 and p<0.001, respectively). Besides, there was a significant correlation between Syntax score and HbA1c (r=0.768 and p<0.001).
DISCUSSION AND CONCLUSION: The Syntax score which, indicates the severity and complexity of CAD, was noted to have a significant positive correlation with non-HDL cholesterol, HbA1c, total cholesterol, LDL cholesterol, triglyceride, and a negative correlation with HDL cholesterol.