INTRODUCTION: The prevalence of early coronary artery disease (CAD) is increasing in developed and developing countries. Non-HDL cholesterol includes lipoproteins with a known atherogenic potential. Since the Syntax scoring system is a quantitative and reproducible basic measurement before revascularization, it can show the coronary anatomical severity and complexity. In this study, the relationship between non-HDL cholesterol (Non-HDL-C) and the complexity of CAD was investigated.
METHODS: This is a retrospective study, and 296 patients under 45 years of age who underwent coronary angiography with a diagnosis of acute coronary syndrome between August 2015 and July 2020 were included. Syntax scores of the patients were evaluated by two experienced cardiologists using the 2.28 version on www.syntaxscore.com. Non-HDL-C levels were calculated by subtracting HDL cholesterol from total cholesterol. Patients' clinical, demographic data, laboratory values, and Syntax score were compared.
RESULTS: The mean Syntax score of the patients was 16.7 ± 6.5. There was a significant positive correlation between the Syntax score and non-HDL-C (p <0.001), Total cholesterol (p <0.001), LDL-C (p <0.001), Triglyceride (p <0.001), and negative correlation between the Syntax score and HDL-C value (p <0.001).
DISCUSSION AND CONCLUSION: The Syntax score which indicates the severity and complexity of CAD, had a significant positive correlation with non-HDL-C, HbA1c, Total Cholesterol, LDL-C, Triglyceride, and a negative correlation with HDL-C.