E-ISSN 2651-3455 (Online) | ISSN 2630-5593 (Print)
Evaluation of Levels of Serum IgE and Rectal Mucosal Eosinophilia in Irritable Bowel Syndrome [anatol j fm]
anatol j fm. 2019; 2(2): 73-77 | DOI: 10.5505/anatoljfm.2018.25733

Evaluation of Levels of Serum IgE and Rectal Mucosal Eosinophilia in Irritable Bowel Syndrome

Esra Elif Akkuş1, Sabah Tüzün2, Kayhan Başak3, Kürşat Epöztürk4, Mehmet Sayıner5, Mustafa Reşat Dabak2
1Mudanya Güzelyalı Family Health Center, Bursa Health Directorate, Bursa, Turkey
2Department of Family Medicine, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey
3Department of Pathology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey
4Department of Allergy, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey
5Department of Medicine, Invova Fairfax Hospital, Falls Church, VA, USA

INTRODUCTION: Irritable bowel syndrome (IBS) and food allergic reactions are common in the community and can cause symptoms similar to each other. In this study, it is aimed to evaluate serum immunglobulin E (IgE) and rectum mucosal eosinophilia levels in IBS.
METHODS: Record of patients who applied between April 2013 and April 2014 were retrospectively screened and patients who were 18–70 years old and previously performed rectal biopsy by colonoscopy and diagnosed with IBS according to Rome III criteria were included in the study. All patients were grouped as diarrheal dominant IBS (IBS-D), constipation dominant IBS (IBS-C), mix type IBS (IBS-M) and unclassified IBS (IBS-U) according to their symptoms. In addition, serum IgE levels and rectal mucosal eosinophilia levels were evaluated from all patients' records.
RESULTS: 39 (56.52%) of total 69 patients with IBS were in the IBS-C group, 19 (27.54%) of them were in the IBS-D, 9 (13.04%) of them were in the IBS-M and 2 (2.90%) of them were in the IBS-U. There were not any significant differences between IBS subgroups in terms of presence of allergic disease and presence of food allergy (p=0.519 and p=0.849, respectively). The median level of rectal eosinophilia in IBS subgroups was found to be 2.00 (0.00 to 88.00) in IBS-C subgroup, 5.00 (0.00–100.00) in IBS-D subgroup and 2.00 (0.00 to 11.00) in IBS-M subgroup. In addition, IgE levels were found high in 7 (19.45%) of IBS-C subgroup, 7 (36.84%) of IBS-D subgroup and 3 (33.33%) of IBS-M group (p=0.348).
DISCUSSION AND CONCLUSION: In this study, relation between serum IgE and rectal eosinophilia levels with IBS subgroups could not not found.

Keywords: Abdominal pain, defecation, diarrhea, irritable bowel syndrome

Esra Elif Akkuş, Sabah Tüzün, Kayhan Başak, Kürşat Epöztürk, Mehmet Sayıner, Mustafa Reşat Dabak. Evaluation of Levels of Serum IgE and Rectal Mucosal Eosinophilia in Irritable Bowel Syndrome. anatol j fm. 2019; 2(2): 73-77

Corresponding Author: Esra Elif Akkuş, Türkiye
Manuscript Language: English
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