INTRODUCTION: The aim of this study was to determine the effects of 8 weeks aerobic exercise program on the inflammatory parameters and Framingham risk score in patients with high cardiac risk and the differences from the patients treated only with medical therapy.
METHODS: The patients with high cardiac risk according to NCEP ATP III criteria (coronary artery disease equivalent or patients with 10-year cardiac risk ≥ % 20) were studied. Totally 50 patients were included in the study. 25 patients were applied to aerobic exercise program for 30 minutes/day for 3 days in a week. There were 25 patients in the control group. Medical treatment was given to all patients according to the guidelines. No complication occurred during the exercise program.
RESULTS: Fifty patients were studied (% 80 women, % 20 men). Their ages were varied between 50-72 years and the mean age was 61+5 years. High sensitive CRP levels were decreased in both groups but much more reduction was observed in exercise group (p<0.001). Homoscysteine and fibrinogen levels were not changed in control group, however significant decrease in aerobic exercise program group (p<0.001, p=0.003). Framingham risk score was decreased significantly in each group at the end of study. Any significant difference was found between these two groups in risk reduction.
DISCUSSION AND CONCLUSION: Regular aerobic exercise is effective and safe to prevent probable cardiovascular events in high cardiac risk patients in addition to medical therapy.